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GENERAL
TITLE
A BIPHENYL INHIBITOR OF EIF4E TARGETING AN INTERNAL BINDING SITE ENABLES THE DESIGN OF CELL-PERMEABLE PROTAC-DEGRADERS
DATE LAST MODIFIED
5 May 2021
RELEASE
28 Apr 2021
OBSOLETE
CLASSIFICATION
PROTEIN BINDING
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
1.91
RESOLUTION RANGE LOW
60.65
PUBMED ID
DOI
10.1016/J.EJMECH.2021.113435
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P06730 EIF4E, EIF4EL1, EIF4F ESCHERICHIA COLI HUMAN
EIF-4E,EIF4E,EIF-4F 25 KDA SUBUNIT,MRNA CAP-BINDIN ...
Mutations
P06730 EIF4E, EIF4EL1, EIF4F ESCHERICHIA COLI HUMAN
EIF-4E,EIF4E,EIF-4F 25 KDA SUBUNIT,MRNA CAP-BINDIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402