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GENERAL
TITLE
CRYO-EM STRUCTURE OF THE AGONIST SETMELANOTIDE BOUND TO THE ACTIVE MELANOCORTIN-4 RECEPTOR (MC4R) IN COMPLEX WITH THE HETEROTRIMERIC GS PROTEIN AT 2.6 A RESOLUTION.
DATE LAST MODIFIED
-
RELEASE
17 Nov 2021
OBSOLETE
CLASSIFICATION
SIGNALING PROTEIN
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
2.58
RESOLUTION RANGE LOW
2.58
PUBMED ID
DOI
10.1038/S41422-021-00569-8
PDBe
--

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P96618 GNAS, GNAS1, GSP TRICHOPLUSIA NI HUMAN
ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN
Q8BYR2 GNB1 TRICHOPLUSIA NI RAT
TRANSDUCIN BETA CHAIN 1
P96618 GNG2 TRICHOPLUSIA NI BOVINE
G GAMMA-I
Q5SXA9 -- ESCHERICHIA COLI LAMA GLAMA --
P96618 -- -- SYNTHETIC CONSTRUCT --
Q8BYR2 MC4R SPODOPTERA AFF. FRUGIPERDA 1 BOLD-2017 HUMAN
MC4-R
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402