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GENERAL
TITLE
CRYSTAL STRUCTURE OF KRAS G12D WITH COMPOUND 36 (4-[(1R,5S)-3,8- DIAZABICYCLO[3.2.1]OCTAN-3-YL]-7-(8-ETHYNYL-7-FLUORONAPHTHALEN-1-YL)- 8-FLUORO-2-{[(4S,7AS)-TETRAHYDRO-1H-PYRROLIZIN-7A(5H)- YL]METHOXY}PYRIDO[4,3-D]PYRIMIDINE) BOUND
DATE LAST MODIFIED
9 Mar 2022
RELEASE
22 Dec 2021
OBSOLETE
CLASSIFICATION
HYDROLASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 21 21 21
RESOLUTION RANGE HIGH
1.29
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.1C01688
LIGANDS
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Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P09879 KRAS, KRAS2, RASK2 ESCHERICHIA COLI HUMAN
K-RAS 2,KI-RAS,C-K-RAS,C-KI-RAS
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402