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GENERAL
TITLE
CRYO-EM STRUCTURE OF THE NON-ACYLATED TIRZEPATIDE (LY3298176)-BOUND HUMAN GLP-1R-GS COMPLEX
DATE LAST MODIFIED
16 Mar 2022
RELEASE
2 Mar 2022
OBSOLETE
CLASSIFICATION
STRUCTURAL PROTEIN
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
3
RESOLUTION RANGE LOW
3
PUBMED ID
DOI
10.1038/S41467-022-28683-0
PDBe
--
LIGANDS
--
Chains
| Structure Chain | Target Protein | Gene | Expression System | Organism | Synonims | Actions |
|---|---|---|---|---|---|---|
| GNAS, GNAS1, GSP | SPODOPTERA FRUGIPERDA | HUMAN | ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN | |||
| P54311 | GNB1 | SPODOPTERA FRUGIPERDA | RAT | TRANSDUCIN BETA CHAIN 1 | Mutations | |
| P63212 | GNG2 | SPODOPTERA FRUGIPERDA | BOVINE | G GAMMA-I | Mutations | |
| Q96RU3 | -- | ESCHERICHIA COLI | ESCHERICHIA COLI | -- | ||
| -- | -- | HOMO SAPIENS | -- | |||
| P43220 | GLP1R | SPODOPTERA FRUGIPERDA | HUMAN | GLP-1 RECEPTOR,GLP-1-R,GLP-1R | Mutations |
NGL Viewer is used for the molecular visualization.
- AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
- AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402