FEATURES

FAMILY

DESCRIPTION

Also known as KCNU1_HUMAN, KCNU1, KCNMA3, KCNMC1, SLO3. Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. Homotetramer; which constitutes the calcium-activated potassium channel. May interact with LRRC52; this interaction may change channel gating properties, such as shifting gating to more negative potentials at a given pH.

EXTERNAL LINKS

KCNU1

Potassium channel subfamily U member 1

KCNU1

Molecular Synopsis