FEATURES

FAMILY

DESCRIPTION

Also known as SUMO5_HUMAN, SUMO1P1, SUMO5, UBL2, UBL6. Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs). PolySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB. SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4-mediated disruption of PML-NBs. Interacts with CBX4 (PubMed:27211601). Interacts with PIAS1 (PubMed:27211601). Found in a complex with SAE2 (PubMed:27211601). Interacts with UBE2I (PubMed:27211601). Interacts with SP100 (PubMed:27211601). Interacts with HIPK2 (PubMed:27211601). Interacts with DAXX (PubMed:27211601). Interacts with PML-RARA oncoprotein; PML-RARalpha outcompetes PML for SUMO1P1/SUMO5 conjugation (PubMed:27211601).

EXTERNAL LINKS

SUMO1P1

Small ubiquitin-related modifier 5

SUMO1P1

Molecular Synopsis