FEATURES

FAMILY

DESCRIPTION

Also known as BMR1B_HUMAN, BMPR1B. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction. Interacts with high affinity with GDF5; positively regulates chondrocyte differentiation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BMPR1B

Bone morphogenetic protein receptor type-1B

BMPR1B

Molecular Synopsis