FEATURES

FAMILY

quiescin-sulfhydryl oxidase (QSOX) family

DESCRIPTION

Also known as QSOX1_HUMAN, QSOX1, QSCN6. Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

QSOX1

Sulfhydryl oxidase 1

QSOX1

Molecular Synopsis