FEATURES

FAMILY

DESCRIPTION

Also known as P3C2B_HUMAN, PIK3C2B. Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns (PubMed:10805725, PubMed:9830063, PubMed:11533253). Does not phosphorylate PtdIns(4, 5)P2 (PubMed:9830063). May be involved in EGF and PDGF signaling cascades (PubMed:10805725). Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PIK3C2B

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

PIK3C2B

Molecular Synopsis