FEATURES

DESCRIPTION

Also known as SOCS6_HUMAN, SOCS6, CIS4, SOCS4. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. Interacts with RBCK1. Interacts with phosphorylated IRS4 (By similarity). Interacts with PIM3 (By similarity). Interacts with KIT (phosphorylated).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SOCS6

Suppressor of cytokine signaling 6

SOCS6

Molecular Synopsis