FEATURES

FAMILY

DESCRIPTION

Also known as HS3S1_HUMAN, HS3ST1, 3OST, 3OST1. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HS3ST1

Heparan sulfate glucosamine 3-O-sulfotransferase 1

HS3ST1

Molecular Synopsis