FEATURES

DESCRIPTION

Also known as AREL1_HUMAN, AREL1, KIAA0317. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). Interacts with SOCS2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AREL1

Apoptosis-resistant E3 ubiquitin protein ligase 1

AREL1

Molecular Synopsis