FEATURES

FAMILY

DESCRIPTION

Also known as SYNJ2_HUMAN, SYNJ2, KIAA0348. Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SYNJ2

Synaptojanin-2

SYNJ2

Molecular Synopsis