FEATURES

FAMILY

DESCRIPTION

Also known as PPM1D_HUMAN, PPM1D, WIP1. Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity). Interacts with CHEK1 and CHEK2; dephosphorylates them. Interacts with MAPK14 (PubMed:21283629).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PPM1D

Protein phosphatase 1D

PPM1D

Molecular Synopsis