FEATURES

FAMILY

DESCRIPTION

Also known as GRM6_HUMAN, GRM6, GPRC1F, MGLUR6. G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GRM6

Metabotropic glutamate receptor 6

GRM6

Molecular Synopsis