FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE8A_HUMAN, PDE8A. Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). Interacts with RAF1. The interaction promotes RAF1 activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDE8A

High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A

PDE8A

Molecular Synopsis