FEATURES

FAMILY

DESCRIPTION

Also known as I18RA_HUMAN, IL18RAP, IL1R7. Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). Forms a ternary complex with IL18 and IL18R1 (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable).

Also known as I18RA_HUMAN, IL18RAP, IL1R7. Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activ ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IL18RAP

Interleukin-18 receptor accessory protein

IL18RAP

Molecular Synopsis