FEATURES

DESCRIPTION

Also known as DTX_CORBE, DTX. Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A. Homodimer.

Also known as DTX_CORBE, DTX. Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribo ...

EXTERNAL LINKS

uniprot
enzyme classification

DTX

Diphtheria toxin

DTX

Molecular Synopsis