FEATURES

FAMILY

DESCRIPTION

Also known as TNFB_HUMAN, LTA, TNFB, TNFSF1. Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14 (PubMed:9462508).

Also known as TNFB_HUMAN, LTA, TNFB, TNFSF1. Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LTA

Lymphotoxin-alpha

LTA

Molecular Synopsis