FEATURES

FAMILY

monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family

DESCRIPTION

Also known as KEFC_ECOLI, kefC, trkC. Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Can also export rubidium, lithium and sodium. Homodimer. Interacts with the regulatory subunit KefF, forming a heterotetramer with 2:2 stoichiometry. Interaction with KefF is required for optimal activity. The active antiporter may be formed by the heterotetramer, or by an octamer.

EXTERNAL LINKS

uniprot
enzyme classification

kefC

Glutathione-regulated potassium-efflux system protein KefC

Mutations

Mutation(s) distribution

Mutations table

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