FEATURES

FAMILY

DESCRIPTION

Also known as HYEP_HUMAN, EPHX1, EPHX, EPOX. Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EPHX1

Epoxide hydrolase 1

EPHX1

Molecular Synopsis