FEATURES

FAMILY

DESCRIPTION

Also known as HEM3_HUMAN, HMBS, PBGD, UPS. As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen (PubMed:18936296, PubMed:19138865, PubMed:23815679). Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact (PubMed:18936296). Monomer.

Also known as HEM3_HUMAN, HMBS, PBGD, UPS. As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HMBS

Porphobilinogen deaminase

HMBS

Molecular Synopsis