FEATURES

FAMILY

cation transport ATPase (P-type) (TC 3.A.3) family

DESCRIPTION

Also known as AT1A3_HUMAN, ATP1A3. This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Interacts with regulatory subunit FXYD1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATP1A3

Sodium/potassium-transporting ATPase subunit alpha-3

ATP1A3

Molecular Synopsis