FEATURES

FAMILY

DESCRIPTION

Also known as FOLR2_HUMAN, FOLR2. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FOLR2

Folate receptor beta

FOLR2

Molecular Synopsis