FEATURES

FAMILY

DESCRIPTION

Also known as TYRO_HUMAN, TYR. This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3, 4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5, 6-dihydroxyindole) to indole-5, 6 quinone (By similarity). Forms an OPN3-dependent complex with DCT in response to blue light in melanocytes.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TYR

Tyrosinase

TYR

Molecular Synopsis