FEATURES

DESCRIPTION

Also known as XRCC1_HUMAN, XRCC1. Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

XRCC1

DNA repair protein XRCC1

XRCC1

Molecular Synopsis