FEATURES

FAMILY

carnitine/choline acetyltransferase family

DESCRIPTION

Also known as CPT2_HUMAN, CPT2, CPT1. Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites (PubMed:20538056, PubMed:24780397). Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters (PubMed:20538056).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CPT2

Carnitine O-palmitoyltransferase 2, mitochondrial

CPT2

Molecular Synopsis