FEATURES

DESCRIPTION

Also known as IBP6_HUMAN, IGFBP6, IBP6. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225). Interacts (via C-terminal domain) with PHB2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

IGFBP6

Insulin-like growth factor-binding protein 6

IGFBP6

Molecular Synopsis