FEATURES

FAMILY

DESCRIPTION

Also known as CXCR1_HUMAN, CXCR1, CMKAR1, IL8RA. Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CXCR1

C-X-C chemokine receptor type 1

CXCR1

Molecular Synopsis