FEATURES

FAMILY

DESCRIPTION

Also known as 5HT1E_HUMAN, HTR1E. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HTR1E

5-hydroxytryptamine receptor 1E

HTR1E

Molecular Synopsis