FEATURES

FAMILY

DESCRIPTION

Also known as FMO3_HUMAN, FMO3. Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FMO3

Dimethylaniline monooxygenase [N-oxide-forming] 3

FMO3

Molecular Synopsis