FEATURES

FAMILY

DESCRIPTION

Also known as GBP1_HUMAN, GBP1. Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. Homodimer; homodimerization occurs upon GTP-binding and is required for the second hydrolysis step from GDP to GMP. Heterodimer with other family members, including GBP2, GBP3, GBP4 and GBP5. Dimerization regulates subcellular location to membranous structures.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GBP1

Guanylate-binding protein 1

GBP1

Molecular Synopsis