FEATURES

FAMILY

DESCRIPTION

Also known as CP2CI_HUMAN, CYP2C18. A cytochrome P450 monooxygenase involved in retinoid metabolism. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may modulate atRA signaling and clearance. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CYP2C18

Cytochrome P450 2C18

CYP2C18

Molecular Synopsis