FEATURES

FAMILY

DESCRIPTION

Also known as KTNA1_CAEEL, mei-1. Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner (PubMed:28783150). Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles (PubMed:8027178, PubMed:10809666, PubMed:12885567, PubMed:19087961, PubMed:23918937). In body wall muscles, regulates organization of myosin thick filaments (PubMed:22621901). Homohexamer; ATP hydrolysis initiates a cycle between an open spiral and a closed ring conformation which is probably involved in pulling tubulin dimers out from microtubules (PubMed:28783150). Interacts with mei-2, which may serve as a targeting subunit (PubMed:10809666). Interacts with mel-26, which targets mei-1 for ubiquitin mediated proteolysis (PubMed:13679921, PubMed:14528312, PubMed:23918937). Interacts with phosphatase pph-4.1 (PubMed:19087961).

EXTERNAL LINKS

mei-1

Meiotic spindle formation protein mei-1

mei-1

Molecular Synopsis