FEATURES

FAMILY

DESCRIPTION

Also known as TIMP3_HUMAN, TIMP3. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TIMP3

Metalloproteinase inhibitor 3

TIMP3

Molecular Synopsis