FEATURES

FAMILY

carnitine/choline acetyltransferase family

DESCRIPTION

Also known as CACP_HUMAN, CRAT, CAT1. Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation (PubMed:15099582, PubMed:29395073). Responsible for the synthesis of short- and branched-chain acylcarnitines (PubMed:23485643). Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates (PubMed:23485643). Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates (PubMed:23485643). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRAT

Carnitine O-acetyltransferase

CRAT

Molecular Synopsis