FEATURES

FAMILY

DESCRIPTION

Also known as MP2K3_HUMAN, MAP2K3, MEK3, MKK3, PRKMK3, SKK2. Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866).

Also known as MP2K3_HUMAN, MAP2K3, MEK3, MKK3, PRKMK3, SKK2. Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a th ...

EXTERNAL LINKS

MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3

MAP2K3

Molecular Synopsis