FEATURES

FAMILY

DESCRIPTION

Also known as LSS_HUMAN, LSS, OSC. Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2, 3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:7639730, PubMed:26200341). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341). Monomer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LSS

Lanosterol synthase

LSS

Molecular Synopsis