FEATURES

FAMILY

DESCRIPTION

Also known as INAR2_HUMAN, IFNAR2, IFNABR, IFNARB. Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway (PubMed:26424569, PubMed:28165510, PubMed:32972995). Directly involved in signal transduction through its association with the TYR kinase JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Involved in interferon-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569, PubMed:32972995)., Potent inhibitor of type I IFN receptor activity. Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453, PubMed:28165510). Interacts with JAK1 (PubMed:8181059, PubMed:7759950). Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and therefore type I interferon signaling (PubMed:28165510).

Also known as INAR2_HUMAN, IFNAR2, IFNABR, IFNARB. Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway (PubMed:26424569, PubMed:28165510, PubMed ...

EXTERNAL LINKS

IFNAR2

Interferon alpha/beta receptor 2

IFNAR2

Molecular Synopsis