FEATURES

FAMILY

monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

DESCRIPTION

Also known as SL9A3_HUMAN, SLC9A3, NHE3. Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Interacts with AHCYL1; the interaction is required for SLC9A3 activity (PubMed:18829453, PubMed:20584908).

EXTERNAL LINKS

SLC9A3

Sodium/hydrogen exchanger 3

SLC9A3

Molecular Synopsis