FEATURES

FAMILY

DESCRIPTION

Also known as DNLI3_HUMAN, LIG3. Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). Isoform 3 interacts (via BRCT domain) with the nuclear DNA-repair protein XRCC1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

LIG3

DNA ligase 3

LIG3

Molecular Synopsis