FEATURES

DESCRIPTION

Also known as KNTC1_HUMAN, KNTC1, KIAA0166. Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Interacts with ZW10; the interaction is required for stable association with the kinetochore. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH; in the complex interacts directly with ZWILCH.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KNTC1

Kinetochore-associated protein 1

KNTC1

Molecular Synopsis