FEATURES

FAMILY

DESCRIPTION

Also known as DUS3_HUMAN, DUSP3, VHR. Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. Interacts with VRK3, which seems to activate it's phosphatase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DUSP3

Dual specificity protein phosphatase 3

DUSP3

Molecular Synopsis