FEATURES

FAMILY

DESCRIPTION

Also known as MMP16_HUMAN, MMP16, C8orf57, MMPX2. Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.

Also known as MMP16_HUMAN, MMP16, C8orf57, MMPX2. Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MMP16

Matrix metalloproteinase-16

MMP16

Molecular Synopsis