FEATURES

FAMILY

DESCRIPTION

Also known as NEK4_HUMAN, NEK4, STK2. Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. Interacts with RPGRIP1 and RPGRIP1L.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NEK4

Serine/threonine-protein kinase Nek4

NEK4

Molecular Synopsis