FEATURES

FAMILY

DESCRIPTION

Also known as UB2E1_HUMAN, UBE2E1, UBCH6. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Interacts with RNF14.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

UBE2E1

Ubiquitin-conjugating enzyme E2 E1

UBE2E1

Molecular Synopsis