FEATURES

DESCRIPTION

Also known as RGS8_HUMAN, RGS8. Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity). Interacts with GNAO1 (By similarity). Interacts with GNAI3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RGS8

Mutations

Mutation(s) distribution

Mutations table