FEATURES

FAMILY

DESCRIPTION

Also known as ACTHR_HUMAN, MC2R, ACTHR. Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MC2R

Adrenocorticotropic hormone receptor

MC2R

Molecular Synopsis