FEATURES

FAMILY

sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family

DESCRIPTION

Also known as SC6A3_HUMAN, SLC6A3, DAT1. Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Homooligomer; disulfide-linked (Ref.14). Interacts with PRKCABP and TGFB1I1 (PubMed:11343649, PubMed:12177201). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (PubMed:15505207). Interacts with alpha-synuclein/SNCA (PubMed:26442590).

Also known as SC6A3_HUMAN, SLC6A3, DAT1. Amine transporter (PubMed:1406597, PubMed:8302271, PubMed:15505207). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into ...

EXTERNAL LINKS

SLC6A3

Sodium-dependent dopamine transporter

SLC6A3

Molecular Synopsis