FEATURES

FAMILY

DESCRIPTION

Also known as GSTM4_HUMAN, GSTM4. Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:8203914, PubMed:8373352). Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 (PubMed:27791009). Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S), 14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GSTM4

Glutathione S-transferase Mu 4

GSTM4

Molecular Synopsis